An Innovative Photogrammetric System for 3D Digitization of Dental Models

This paper presents an innovative system for 3D reconstruction of a physical dental model. The innovative system is based on close-range photogrammetry and enables the projection of digital light texture on the objects surface. It is based on the application of mirrors that direct the digital light texture to the vertical surfaces of the physical model. In this way, high coverage of the object is achieved, and 3D reconstruction from one set of photographs is possible. 3D digitization, verification and comparison of the proposed methodology was performed on dental models that are characterized by extremely complex surfaces. It was performed by comparing the proposed approach with active stereovision, and the efficiency was evaluated in relation to the reference 3D model obtained by the structured light 3D scanner. The comparison of the results was performed on the basis of the mean deviation and standard deviation for the 3D model with combined teeth and for the 3D model with metal caps. The absolute mean deviations for the 3D model with combined teeth are 0.004-0.021 mm, with a standard deviation of 0.055-0.058 mm, and for the 3D model with metal caps absolute mean deviations are 0.015-0.033 mm, with a standard deviation of 0.095-0.113 mm, respectively. Absolute minimum values of mean deviation of 0.004 mm and standard deviations of 0.055 mm were obtained by 3D model with combined teeth,which was reconstructed by the proposed innovative approach. The obtained results indicate a higher accuracy of the innovative approach in relation to the use of a commercial 3D scanner that uses active stereovision principle

An empirical study of employee loyalty, service quality, cost reduction and company performance

The focus of this study was on investigating the relationships among employee loyalty, service quality, cost reduction and company performance, with the aim to investigate the impact of employee loyalty to company performance. The research model was developed and empirically tested on the sample of 100 service companies with 317 questionnaire surveys conducted in the Republic of Serbia and Bosnia and Herzegovina. Using different statistical analysis (the Kolmogorov-Smirnovljev statistic, Path analysis, A.M.O.S. statistic software and lavaan software) leads to the conclusion that employee loyalty is significantly related and has a positive influence on company performance

The NO-modified HIV protease inhibitor as a valuable drug for hematological malignancies: Role of p70S6K

Covalent attachment of NO to the first approved HIV protease inhibitor Saquinavir (Saq-NO) expands the therapeutic potential of the original drug. Apart from retained antiviral activity, the modified drug exerts strong antitumor effects and lower toxicity. In the present study, we have evaluated the sensitivity of different hematological malignancies to Saq-NO. Saq-NO efficiently diminished the viability of Jurkat, Raji, HL-60 and K562 cells. While Jurkat and Raji cells (established from pediatric patients) displayed abrogated proliferative potential, HL-60 and K652 cells (originated from adults) exposed to Saq-NO treatment underwent caspase dependent apoptosis. In addition, similar sensitivity to Saq-NO was observed in mononuclear blood cells obtained from pediatric patients with acute lymphoblastic leukemia (ALL) and adult patients with acute myeloid leukemia (AML). Western blot analysis indicated p70S6 kinase as a possible intracellular target of Saq-NO action. Moreover, the addition of a NO moiety to Lopinavir resulted in improved antitumor potential as compared to the parental compound, suggesting that NO-derived HIV protease inhibitors are a potential new source of anticancer drugs with unique mode of action. (C) 2015 Elsevier Ltd. All rights reserved

Genotype phenotype correlation in a pediatric population with antithrombin deficiency

L

Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Acute Lymphoblastic Leukemia Intercontinental-Berlin-Frankfurt-Münster 2009 Trial

Purpose: The International Berlin-Frankfurt-Münster (BFM) study group conducted a study on pediatric acute lymphoblastic leukemia (ALL). Minimal residual disease (MRD) was assessed using flow cytometry (FCM), and the impact of early intensification and methotrexate (MTX) dose on survival was evaluated. Patients and methods: We included 6,187 patients younger than 19 years. MRD by FCM refined the risk group definition previously used in the ALL intercontinental-BFM 2002 study on the basis of age, WBC count, unfavorable genetic aberrations, and treatment response measured morphologically. Patients at intermediate risk (IR) and high risk (HR) were randomly assigned to protocol augmented protocol I phase B (IB) versus IB regimen. MTX doses of 2 versus 5 g/m2 every 2 weeks, four times, were evaluated in precursor B-cell-ALL (pcB-ALL) IR. Results: The 5-year event-free survival (EFS ± SE) and overall survival (OS ± SE) rates were 75.2% ± 0.6% and 82.6% ± 0.5%, respectively. Their values in risk groups were standard risk (n = 624), 90.7% ± 1.4% and 94.7% ± 1.1%; IR (n = 4,111), 77.9% ± 0.7% and 85.7% ± 0.6%; and HR (n = 1,452), 60.8% ± 1.5% and 68.4% ± 1.4%, respectively. MRD by FCM was available in 82.6% of cases. The 5-year EFS rates in patients randomly assigned to protocol IB (n = 1,669) and augmented IB (n = 1,620) were 73.6% ± 1.2% and 72.8% ± 1.2%, respectively (P = .55), while those in patients receiving MTX doses of 2 g/m2 (n = 1,056) and MTX 5 g/m2 (n = 1,027) were 78.8% ± 1.4% and 78.9% ± 1.4%, respectively (P = .84). Conclusion: The MRDs were successfully assessed using FCM. An MTX dose of 2 g/m2 was effective in preventing relapse in non-HR pcB-ALL. Augmented IB showed no advantages over the standard IB. Unlabelled: [Media: see text]